2006

All real-world events relating to the universe that occurred in 2006.

January

 * January 8 – aired for the first time.
 * January 29 – aired for the first time.

February

 * February 24 – Don Knotts died.

March

 * March 12 – aired for the first time.
 * March 20 – was born.
 * March 26 –  aired for the first time.

April

 * April 9 – aired for the first time.
 * April 23 – aired for the first time.
 * April 30 – aired for the first time.

May

 * May 7 – aired for the first time.
 * May 14 –  aired for the first time.
 * May 15 – Semmy Sebastian died.
 * May 21 –
 * aired for the first time.
 * aired for the first time.
 * aired for the first time.
 * The fourth season of started.


 * May 27 – Paul Gleason died.

September

 * September 7 – Ian Chen was born.
 * September 10 – aired for the first time.
 * The fifth season of started.


 * September 17 – aired for the first time.
 * September 24 – aired for the first time.

October

 * October 17 –
 * Family Guy Video Game! was released for the first time.
 * Family Guy: Brian Griffin's Guide to Booze, Broads, and the Lost Art of Being a Man was published.

November

 * November 5 – aired for the first time.
 * November 12 – aired for the first time.
 * November 14 – Family Guy: A Big Book o' Crap! was published.
 * November 19 – aired for the first time.
 * November 24 – Family Guy: Official Annual was published.
 * November 26 – aired for the first time.

December

 * December 17 – aired for the first time.
 * December 25 – James Brown died.