2000

All real-world events relating to the Family Guy universe that occurred in 2000.

February

• February 10 – Yara Shahidi was born.
• February 29 – The animatic for "And the Wiener Is..." is drafted.

March

• March 6 – The storyboards for the first two acts of "One If by Clam, Two If by Sea" are put under "NOT FINAL STORYBOARD" for last double checking before oversea shipping.
• March 7 – "Brian in Love" aired for the first time.
• March 9 – The storyboards for the third act of "One If by Clam, Two If by Sea" are put under "NOT FINAL STORYBOARD" for last double checking before oversea shipping.
• March 14 – "Love Thy Trophy" aired for the first time.
• March 17 - The storyboards for the first two acts of "One If by Clam, Two If by Sea" are finalized and ready for overseas shipping.
• March 21
  • "Death Is a Bitch" aired for the first time.
  • The storyboards for the third act of "One If by Clam, Two If by Sea" are finalized and ready for overseas shipping.
• March 28 – "The King Is Dead" aired for the first time.

April

• April 4
  • "I Am Peter, Hear Me Roar" aired for the first time.
  • "E Peterbus Unum" reaches the Color Draft, with the White label.
• April 6 - "E Peterbus Unum"'s Color Draft is revised, heading into the Pink label.
• April 11 – "If I'm Dyin', I'm Lyin'" aired for the first time.
• April 18 – "Running Mates" aired for the first time.
• April 25 – "A Picture's Worth a Thousand Bucks" aired for the first time.

May

• May 2 – "Fifteen Minutes of Shame" aired for the first time.
• May 30 – "Road to Rhode Island" aired for the first time.

June

• June 6 – "Let's Go to the Hop" aired for the first time.
• June 13 – "Dammit, Janet!" aired for the first time.
• June 20 – "There's Something About Paulie" aired for the first time.
• June 27 – "He's Too Sexy for His Fat" aired for the first time.

July

• July 8 – Benjamin Stockham was born.
• July 11 – "E Peterbus Unum" aired for the first time.
• July 16 – Jonathan Morgan Heit was born.
• July 18 – "The Story on Page One" aired for the first time.
• July 25 –
  • "Wasted Talent" aired for the first time.
  • Mason Cook was born.

August

• August 1 – "Fore, Father" aired for the first time.
  • The second season of Family Guy ended.

Unknown Time Date

• Unknown (presumably around August/early September) - Fox orders a last-minute reprieve of Family Guy, reviving it for a short thirteen-episode third season.

September

• September 7 - The first draft for "Brian Wallows and Peter's Swallows" is made.
• September 13 – The table reading for "Emission Impossible" takes place.

October

• October 11 – The table reading for "Mr. Saturday Knight" takes place.
• October 17 - The model sheets are refined. Peter and Lois lose their eyebrows, Chris' earring(s?) are gone, and Meg's shoes are now grey instead of tan.
• October 25
  • The table reading for "A Fish Out of Water" takes place.
  • The first draft for "Peter Griffin: Husband, Father...Brother?" is completed.

November

• November 1 – The table reading for "Peter Griffin: Husband, Father...Brother?" takes place.

December

• December 14 - The table reading for "Stuck Together, Torn Apart" takes place.