2022

All real-world events relating to the Family Guy universe that occurred in 2022.

January

• January 9 – "Mister Act" aired for the first time.
• January 29 – Jan DeWitt died.

February

• February 27 – "The Lois Quagmire" aired for the first time.

March

• March 6 – "Lawyer Guy" aired for the first time.
• March 13 – "HBO-No" aired for the first time.
• March 20 – "Hard Boiled Meg" aired for the first time.
• March 27 – "Prescription Heroine" aired for the first time.

April

• April 2 – Estelle Harris died.
• April 12 – Gilbert Gottfried died.
• April 30 – Ian Wilcox died.

May

• May 1 – "All About Alana" aired for the first time.
• May 8 – "Girlfriend, Eh?" aired for the first time.
• May 15 – "First Blood" aired for the first time.
• May 22 – "The Jersey Bore" aired for the first time.

• The twentieth season of Family Guy ended.

• May 26 – Ray Liotta died.

June

• June 23 – Tommy Morgan died.

July

• July 6 – James Caan died.
• July 8 – Tony Sirico died.
• July 18 – Vincent DeRosa died.
• July 20 – Terry Harrington died.

August

• August 5 – Mike Lang died.
• August 7 – Roger E. Mosley died.
• August 25 – Jeff Howard died.

September

• September 8 – Elizabeth II died.
• September 25 – "Oscars Guy" aired for the first time.
  • The twenty-first season of Family Guy started.

October

• October 2 – "Bend or Blockbuster" aired for the first time.
• October 9 – "A Wife-Changing Experience" aired for the first time.
• October 13 – Mike Schank died.
• October 16 – "The Munchurian Candidate" aired for the first time.
• October 23 – "Unzipped Code" aired for the first time.
• October 30 – "Happy Holo-Ween" aired for the first time.

November

• November 12 – Gene Cipriano died.
• November 13 – "The Stewaway" aired for the first time.
• November 20 – "Get Stewie" aired for the first time.

December

• December 4 – "Carny Knowledge" aired for the first time.
• December 11 – "The Candidate" aired for the first time.
• December 30 – Barbara Walters died.